Fig 1.
A flow diagram of inclusion of United States interventional mental health trials registered on ClinicalTrials.gov.
Fig 2.
Characteristics of United States mental health clinical trials registered on ClinicalTrials.gov from January 1, 2008 to December 31, 2017.
(A) The number of mental health clinical trials submitted to the registry by year. (B) Proportion of trials by year stratified by funders. ‘AMC/Hosp/Oth’ denotes Academic Medical Centers/Hospitals/Other. ‘US Govt’ denotes United States Government, which includes NIH (National Institutes of Health) and US Federal agency funders.
Table 1.
Average and compound annual growth rates of all United States mental health and non-mental health trials registered in ClinicalTrials.gov from January 1, 2008 to December 31, 2017.
Table 2.
Characteristics of mental health clinical trials registered in ClinicalTrials.gov from October 1, 2007 to April 30, 2018 stratified by early (2007–2012) and late (2013–2018) time periods.
Table 3.
Characteristics of mental health and non-mental health clinical trials registered in ClinicalTrials.gov from October 1, 2007 to April 30, 2018.
Fig 3.
The proportion of total United States mental health clinical trials registered in ClinicalTrials.gov stratified by DSM-5 disorder categories.
These disorder categories correspond to the disorder index categories in the Section II Diagnostic Criteria and Codes provided by the DSM-5. Refer to S2 Table for a description of the disorders included under each disorder category. Of note, the total percentage of trials in the ‘Disorder’ category is greater than 100%, as some trials studied more than one disorder category and were counted in each category.
Table 4.
Disorders and interventions studied in mental health clinical trials registered in ClinicalTrials.gov from October 1, 2007 to April 30, 2018.
Table 5.
Top fifty sponsors of United States mental health clinical trials registered in ClinicalTrials.gov from October 1, 2007 to April 30, 2018.
Fig 4.
Cumulative incidence of discontinuation among United States mental health clinical trials.
Measured from time after the trial start date. Stratified by funder type. AMC/Hosp/Oth’ denotes Academic Medical Centers/Hospitals/Other. ‘US Govt’ denotes United States Government, which includes NIH (National Institutes of Health) and US Federal agency funders.
Table 6.
Cox proportional hazards regression analysis of factors associated with United States mental health trial discontinuation.
Table 7.
Logistic regression analysis of United States mental health trial characteristics associated with reporting results to ClinicalTrials.gov within 36 months of trial completion.