Fig 1.
Hemodynamic Tissue Signature pipeline in ONCOhabitats.
Fig 2.
Box-Whiskers representation of rCBVmax at each vascular habitat for every Verhaak subtype.
Horizontal lines show the significant results of Mann-Whitney tests. * for statistical significance with p<0.05; ** for statistical significance with p<0.01; All p-values are multiple test corrected. HAT = high angiogenic tumor, LAT = low angiogenic tumor, IPE = infiltrated peripheral edema, VPE = vasogenic peripheral edema.
Table 1.
Mean and standard deviation for rCBVmean, rCBVmedian and rCBVmax at enhanced tumor (ET) and at infiltrated peripheral edema (IPE) habitat, and p-values from ANOVA and Kruskal-Wallis (K-W) tests in every subtype: Classical (Cla), mesenchymal (Mes), neural (Neu) and proneural (Pro).
Fig 3.
Kernel smoothed density distribution for rCBV values at infiltrated peripheral edema for each patient and molecular signature.
Dotted lines represent density distribution for each patient. Solid lines represent the mean density distribution of patients grouped by molecular subtype.
Table 2.
Mann Whitney U-test p-values comparing rCBV values at infiltrated peripheral edema habitat in each subtype against the others individually and rCBV values of each subtype against the rest.
Table 3.
Cox proportional hazards regression results for a total of 9 models: Uniparametric using rCBVmax at infiltrated peripheral edema (IPE) and Verhaak subtypes and multiparametric using their combination.