Fig 1.
PRISMA flowchart depicting the literature search and gene extraction.
Table 1.
Baseline demographic and clinical characteristics of participants.
Table 2.
Genes primarily linked to cervical insufficiency (first list of genes).
Fig 2.
Each circle represents one of the three gene lists generated in the study.
The smaller the list, the closer the association with cervical insufficiency. The number of genes covered in the TruSight NGS kit are mentioned, as well as the number of deleterious variants identified in our patients across each gene list.
Table 3.
Closer analysis of variants most likely contributing to the development of cervical insufficiency in our patients.
Table 4.
Pathway enrichment analysis of genes having rare deleterious variants in patients with cervical insufficiency.