Fig 1.
Schematic of PRIMA system.
Fig 2.
Design of PRIMA retinal implants.
Fig 3.
Diagram of vitrectomy instrumentation entry ports.
Fig 4.
Retinal imaging of a subretinal 1.5mm PRIMA chip implantation in Primate eye before and immediately after surgery.
A: Preoperative fundus photograph of macula in Macaca fascicularis; B: Preoperative optical coherence scan of macula; C: Fundus photograph of right eye 1.5mm subretinal implant with comparative left eye.
Fig 5.
Retinal imaging of a subretinal 2mm PRIMA chip implantation in Primate eye before and immediately after surgery.
A: Preoperative fundus photograph of macula in Macaca fascicularis; B: Preoperative optical coherence scan of macula; C: Enface image of the 2mm retinal implant; D: Horizontal OCT scan showing subretinal location of implant; E: Vertical OCT scan showing subretinal location of implant.
Fig 6.
Retinal imaging of a subretinal 1.5mm PRIMA chip implantation in Primate eye at 2 weeks, 4 weeks, 8 months, and 12 months after surgery.
A: 2 week postoperative optical coherence scan of macula in Macaca fascicularis; B: 4 week postoperative optical coherence scan of macula; C: 8 month postoperative optical coherence scan of macula; D: 12 month postoperative optical coherence scan of macula showing implant stability.
Fig 7.
Intraoperative colour fundus photograph and OCT of 1.5mm multichip in macula of primate.
A: Fundus photograph of two 1.5mm chips; B: OCT scan of 1.5mm chips placed under the macula.
Table 1.
Summary of adverse events for 1.5mm and 2mm PRIMA surgery in primates.
Fig 8.
Intraoperative colour fundus photograph in macula of primate.
Subfoveal 1.5mm chip placement with overlying macular hole and localised retinal detachment at macula.
Fig 9.
Red-free fundus photograph of in Macaca fascicularis.
The 1.5mm implant remains in the central macula at 2 weeks postoperatively.