Fig 1.
Example of measurement of 18F-FET uptake in anatomic brain structures.
A T1-weighted (T1w) MR image, B T2-weighted (T2w) MR image, C fused image PET/MR image. Examples of two volumes-of-interest (VOI) for 18F-FET uptake calculation in physiological structures: putamen (black arrow) and thalamus (white arrow).
Table 1.
Patient demographics, tumors, and reason for 18F-FET-PET.
Table 2.
18F-FET-PET parameters in tumor tissue and normal brain and head structures.
Table 3.
18F-FET-PET reference values for normal brain and head structures.
Table 4.
18F-FET-PET parameters in high-grade and low-grade gliomas.
Fig 2.
A Scatterplot of SUVmax of venous cluster with SUVmax of deep gray matter cluster. B Significant difference in the SUVmax were found for venous cluster (M = 2.25, SD = 0.37) and deep gray matter cluster (M = 1.61, SD = 0.36), paired sample t-test, 1p = 1.0129E-24.
Fig 3.
A Scatterplot of TBR of venous cluster with TBR of deep gray matter cluster. B Significant difference in the TBR values were identified for venous cluster (M = 2.03, SD = 0.46) and deep gray matter cluster (M = 1.42, SD = 0.17), paired sample t-test, 1 p = 6.312E-19.
Fig 4.
A Intra-cluster correlations of the venous cluster vary between 0.42 and 0.67, all highly significant. B Intra-cluster correlations of the deep gray matter cluster vary between 0.38 and 0.82, all highly significant. Sig. (two-tailed): **p < .01. Spearman Rho rank correlation applicable for non-parametric distribution in the scatter plot. Strength of correlation < 0.3 = no correlation, 0.3–0.5 weak, 0.5–0.8 moderate, > 0.8 strong correlation [30].
Fig 5.
A The three different patterns of the TAC of 18F-FET uptake (1 wash-in, 2 plateau, and 3 wash-out) were unequally distributed among the eight structures. B Distribution of the TAC pattern reflects the two clusters venous cluster and deep gray matter cluster. The crosstabulation Pearson’s chi-squared test suggests that the two clusters are not related regarding TAC (χ2 (2) = 126.74, p < .001). N = 70; superior sagittal sinus: n = 67, pineal gland: n = 66 (If tumors were in the superior sagittal sinus or in the pineal gland, no values were recorded from these structures).