Table 1.
Characteristics of eight eyes with progression to exudative AMD.
Table 2.
Baseline profiles of study patients (n = 27).
Fig 1.
The proportions of FAF patterns.
Top: all FAF patterns of 66 eyes at baseline. Middle: FAF patterns at baseline of 27 eyes which were followed-up during the 5 years. Bottom: the final FAF patterns of 27 eyes at the 5th year. The numbers within graphs show the actual number of the eye.
Table 3.
Pattern alterations observed during follow-up.
Fig 2.
Transition of mean retinal sensitivity by each pattern of abnormal FAF during the 5 years.
The number of each pattern differs at each time-point compared to baseline (cf. Fig 1). The sensitivity of the linear, focal plaque-like, patchy, and speckled FAF pattern decreased significantly compared to the baseline at the 5th year. The speckled FAF pattern at the 5th year had the lowest mean retinal sensitivity. The sensitivity of lace-like increased significantly compared to baseline at the 5th year. Data are expressed as mean ± standard error (SE). * P < 0.05 compared to baseline, paired t-test. BL: baseline.
Fig 3.
The association between the mean retinal sensitivity and the distance from the abnormal FAF (1,215 points per year).
Total 1,215 points were classified as “Within” (within abnormal FAF), “Close” (within 1 degree from the border of abnormal FAF), and “Distant” (over 1 degree from the border of abnormal FAF). Data are expressed as mean ± SE.
Table 4.
Results of the random intercept and slope model.
Fig 4.
A representative case of FAF imaging and color fundus imaging.
A 66-year-old man. The focal increase FAF pattern was seen at baseline, and the mean retinal sensitivity was 12.2 dB. In 3 years, the portion showing hyperfluorescence at baseline changed to hypofluorescence in part, and the hyperfluorescence expanded and changed to the patchy pattern. In the fundus photograph, drusen increased during the 5 years. The mean retinal sensitivity was 13.4 dB at the 3rd year and 9.5 dB at the 5th year.