Fig 1.
Efficacy of treating anthrax CNS infection with Ampicillin or Augmentin.
Rabbits were inoculated ICM with vegetative encapsulated Vollum bacteria and treated 6 hr post infection with Meropenem (40 mg/kg), Ampicillin or Augmentin (150 mg/kg). Survival and time to death (Kaplan-Mayer curves) are shown. Statistical significance was P = 0.0001 for Meropenem vs. Ampicillin and P = 0.0779 for Ampicillin vs. Augmentin.
Fig 2.
Effect of compromising the BBB on the efficacy of Ampicillin treatment.
Naïve or pre-immune (Ampicillin 150+Vacc) rabbits were inoculated ICM with encapsulated Vollum bacteria and treated 6 hr post-infection with Ampicillin with the indicated dose (mg/kg) by IV or IV+ICM (Ampicillin 150+ICM). Survival and time to death are shown. Statistical significance P = 0.0779 for Ampicillin 150/300 vs. Ampicillin+ICM/PA.
Fig 3.
Dose effect of Meropenem treatment or anthrax CNS infection.
Naïve rabbits were inoculated ICM with encapsulated Vollum bacteria and treated IV 6 hr post-infection with Meropenem at the indicated dose (mg/kg). Survival and time to death (curves) are shown. Statistical significance P = 0.0475 for Meropenem 40 mg/kg vs. 80 mg/kg and P = 0.26 for Meropenem 80 mg/kg vs. 150 mg/kg. Over all the results indicate a significant positive effect for increasing Meropenem doses beyond 40 mg/kg (P<0/0001).
Fig 4.
Efficacy of Unasyn or Tazocin in treating anthrax CNS infections.
Rabbits were inoculated ICM with vegetative encapsulated Vollum bacteria and treated 6 hr post infection with Unasyn or Tazocin (150 mg/kg). The results of Ampicillin and Augmentin were copied from Fig 1. Survival and time to death are shown. Statistical significance P = 0.3173 for Augmentin vs. Unasyn and P = 0.0009 for Augmentin vs. Tazocin. Over all the results indicate a significant negative effect for the treatment of Tazocin compared to the other treatments (P<0/0001).
Fig 5.
Effect of compromising the BBB on the efficacy of Tazocin treatment.
Naïve or pre-immune (Tazocin 150+Vacc) rabbits were inoculated ICM with encapsulated Vollum bacteria and treated 6 hr post-infection with Tazocin at the indicated dose (mg/kg) by IV or IV+ICM (Tazocin 300+ICM). The results of Unasyn were added from Fig 4. Survival and time to death are shown.