Fig 1.
Heatmap of miRNA expression in CC.
The horizontal axis above indicates the groups of samples. The vertical axis on the left shows the cluster of different miRNAs, and the right axis shows the miRNA name. Red indicates high expression, and green indicates low expression. miRNA, microRNA; CC, colon cancer.
Table 1.
The main clinical and pathological characteristics of the 407 CC patients.
Fig 2.
Survival analysis in the training and validation cohorts.
In the training (a) and validation (b) cohorts, the patients were split into groups of high and low risk. Survival analysis was conducted by Kaplan‐Meier analysis and log-rank test.
Fig 3.
Survival and disease-free survival analyses in the combined cohort.
The survival curve (a) and disease-free survival (b) were calculated for the combined cohort according to the miRNA signature by Kaplan-Meier and log-rank.
Fig 4.
The ROC curve of the miRNA signature for 3-year and 5-year survival probability in the combined cohort. ROC, receiver operating characteristic; miRNA, microRNA.
Fig 5.
A nomogram for predicting the survival probability of CC patients with 1-, 3- and 5-year OS. CC, colon cancer; OS, overall survival.
Table 2.
Thirteen miRNAs were filtered by the single-factor CoxPH regression model.
Table 3.
A multivariate analysis of survival with clinical factors and the miRNA signature.
Fig 6.
The overlapping target genes were predicted using the TargetScan, miRDB, and miRTarBase online analysis tools.
Fig 7.
Biological function and KEGG pathway analyses of target genes.
(a) The enriched GO cellular component terms of target genes. (b) The enriched GO molecular function terms of target genes. (c) The enriched GO biological process terms. (d) The enriched pathways of the target gene determined by KEGG pathway analysis. GO, Gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.