Fig 1.
Flowchart of selection of E. coli blood isolates.
Table 1.
Baseline epidemiological characteristics of E. coli bacteremia episodes.
Fig 2.
ST distribution among non-ESBL-Ec versus ESBL-Eca in order of frequencyb.
ESBL, extended-spectrum beta-lactamase; ESBL-Ec, ESBL-producing E. coli; non-ESBL-Ec, non-ESBL-producing E. coli; ST, sequence type. aESBL-positivity based on phenotypic ESBL production. bMissing STs and STs that occurred ≤3 times are grouped in “Other”. STs that only occurred once are grouped in “Singletons”. The height of each individual bars represents the proportion of the ST within the group of non-ESBL-Ec and ESBL-Ec, respectively. The numbers represent the absolute numbers of occurrence.
Table 2.
Serotype distribution among E. coli blood isolates, stratified for ESBL-positivity.
Fig 3.
Acquired resistance gene count per ST, stratified for ESBL-positivitya.
ESBL, extended-spectrum beta-lactamase; ESBL-Ec, ESBL-producing E. coli; non-ESBL-Ec, non-ESBL-producing E. coli; ST, sequence type. aESBL-positivity based on phenotypic ESBL production. Boxplots display median resistance gene count and inter quartile range (IQR); every dot represents a single isolate. Only STs that occurred >5% within non-ESBL-Ec or ESBL-Ec were grouped into main groups, the rest was categorized as “Other”. Results of the pairwise comparisons between STs can be found in S3 Appendix.
Fig 4.
ExPEC-associated VG score in different STs, stratified for ESBL-positivitya.
ESBL, extended-spectrum beta-lactamase; ESBL-Ec, ESBL-producing E. coli; ExPEC, extra-intestinal pathogenic E. coli; non-ESBL-Ec, non-ESBL-producing E. coli; ST, sequence type; VG, virulence gene. aESBL-positivity based on phenotypic ESBL production. Boxplots display median VG score and inter quartile range (IQR); every dot represents a single isolate. Only STs that occurred >5% within non-ESBL-Ec or ESBL-Ec were grouped into main groups, the rest was categorized as “Other”. Results of pairwise comparisons between STs can be found in S4 Appendix.