Table 1.
Data of 6 patients at the profiling stage.
Table 2.
Demographic data of 22 patients at the validation stage.
Fig 1.
Three candidate miRNAs were identified in synovial fluid samples collected from 6 patients preoperatively and postoperatively after high tibial osteotomy. After adding 4 miRNAs from published literature, a total of 7 miRNAs in 22 patients were validated.
Table 3.
miRNA expression levels in synovial fluid.
Fig 2.
Heat map showing the expression levels of 84 target miRNAs from a miRNA PCR array screening of synovial fluid collected from 6 patients preoperatively and at 6 months postoperatively.
Fig 3.
Box plot showing the interquartile range and median of expression levels of miR-30a-5p, miR-29a-3p, miR-30c-5p, miR-378a-5p, miR-23a-3p, miR-27b-3p, and miR-140-3p at the validation stage.
The values represent the relative levels normalized to the levels of the reference gene SNORD61.
Table 4.
Fold changes of the expression of miRNAs at the profiling and validation stages.
Table 5.
Improvement of radiological and functional outcomes in 22 patients.