Fig 1.
Selection strategy–study inclusion and exclusion flowchart.
HRQOL = health-related quality of life. RCTs = randomized controlled trials. ICIs = immune checkpoint inhibitors. * = some RCTs included more than one ICI.
Table 1.
Key characteristics of 15 RCTs between 2012 and 2019.
Table 2.
Level of reporting according to the minimun standard checklist for evaluating HRQOL outcomes in cancer clinical trials.
Fig 2.
+ = low risk of bias. − = high risk of bias. ? = unclear risk of bias. * = bias due to inadequate generation of a randomised sequence. † = bias due to inadequate concealment of allocations before assignment. § = bias due to knowledge of the allocated interventions by participants and personnel during study. ¶ = detection bias due to knowledge of the allocated interventions by outcome assessment. # = due to amount, nature or handling of incomplete outcome data. ¥ = bias due to selective outcome reporting.