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Fig 1.

Flowchart of study cohort.

PE = pre-eclampsia, SGA = small for gestational age, AGA = appropriate for gestational age.

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Table 1.

Inclusion and exclusion criteria for high-risk women.

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Table 2.

Baseline characteristics of study groups.

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Table 3.

Pregnancy characteristics of study groups.

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Table 4.

Distribution of pre-eclampsia phenotypes.

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Table 5.

Geometric mean plasma hemopexin concentrations (mg/ml) by subgroups at three different sampling points during pregnancy.

A before adjustment for body mass index, B after adjustment for body mass index.

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Table 6.

Geometric mean plasma alpha-1-microglobulin concentration (μg/ml) by subgroups at three different sampling points during pregnancy.

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Fig 2.

Geometric mean of plasma hemopexin concentration in three study groups by duration of gestation.

The geometric means and the 95% confidence intervals (red bars) of the plasma hemopexin (Hpx) concentration among low-risk women (LRW) and high-risk women who did (HRPE) and did not (HRW) develop pre-eclampsia. Data shown by weeks of gestation (A) before and (B) after adjustment for body mass index.

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Fig 3.

Geometric mean of alpha-1-microglobulin concentration in three study groups and in pre-eclamptic women with small for gestational age and appropriate for gestational age fetus by weeks of gestation.

The geometric means of the plasma alpha-1-microglobulin (A1M) concentration by weeks of gestation (A) among low-risk women (LRW) and high-risk women, who developed pre-eclampsia (HRPE) and among high-risk women who did not develop pre-eclampsia (HRW) and (B) among women who developed pre-eclampsia and gave birth to a small for gestational age infant (PESGA) and to an appropriate for gestational age infant (PEAGA). Red bars indicate 95% confidence intervals.

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