Fig 1.
Flow chart of applied systems biology approach in current study.
Fig 2.
Identified meta genes in two data sets at logarithmic (A), transition (B) and production peak (C) phases after the transition from autotrophic to heterotrophic growth mode.
Fig 3.
Distribution of TFs, TRs, and PKs families identified in meta genes.
The number TF families (A, B and C), TRs families (D, E, and F), PKs families (G, H, and I) in meta genes at LG, TR and PR phases, respectively.
Fig 4.
Hierarchical cluster constructed with WGCNA at LG (A), TR (B), and PR (C) phases. Each vertical line (leaf) represents the corresponding genes.
Fig 5.
Visual representation of the changes in the module structure between LG (A), TR (B), and PR (C) phases. Modules are illustrated with different colors.
Table 1.
Details of conservation analysis of defined modules at different developmental phases with permutation=200.
Fig 6.
PPI networks of co-expressed meta genes in brown module at LG (A), TR (B), and PR (C) phases. Changes in intra-module connectivity are highlighted at different phases.
Table 2.
Functional enrichment of non-preserved module based on KEGG database.