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Fig 1.

Study flow diagram.

ESD, endoscopic submucosal dissection; EGC, early gastric cancer.

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Table 1.

Patient characteristics.

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Table 2.

Lesion characteristics of 1st ESD.

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Table 3.

Final pathology result of surgery group.

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Table 4.

Clinical outcomes of the gastric cancers after 1st ESD according to additional treatment.

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Fig 2.

Kaplan-Meier plots for overall survival (A), disease-specific survival (B), and disease-free survival (C) in all the patients. OS, overall survival; DSS, disease-specific survival; DFS, disease-free survival.

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Fig 3.

Kaplan-Meier plots for overall survival (A), disease-specific survival (B), and disease-free survival (C) according to treatment type: observation group (green line) versus surgery group (blue line). Disease-free survival (residual + synchronous + metachronous tumor) (D) and disease-free survival (regional LN + distant metastasis) (E) in the observation group. OS, overall survival; DSS, disease-specific survival; DFS, disease-free survival; LN, lymph node.

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Fig 4.

Comparison of time to recurrence between the two groups.

(P = 0.036) observation group (green) versus surgery group (blue).

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Table 5.

Risk factors for residual tumor, residual tumor with depth ≥T2, synchronous tumor and regional LN metastasis of beyond expanded criteria of ESD for EGC.

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Table 6.

Regional LN metastasis risk according to risk group as defined by the prognostic model.

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