Table 1.
Patient characteristics at first NSAA assessment.
Fig 1.
NSAA total score trajectories for individual patients by age (in grey) and the fitted mean and 95% confidence interval (in black). Each grey line represents NSAA total scores from an individual patient plotted versus age; the population mean and its 95% confidence bands are shown in black. NSAA, North Star Ambulatory Assessment.
Fig 2.
Histograms of changes in NSAA total scores over (A) 1 year, (B) 2 years, and (C) 3 years among boys with DMD belonging to different age ranges. DMD, Duchenne muscular dystrophy; NSAA, North Star Ambulatory Assessment.
Fig 3.
Individual patient (A) and fitted mean (B) trajectories of NSAA total score by latent class; individual patient trajectories of (C) 10 metre walk/run velocity and (D) velocity of timed rise from supine, all stratified by latent class. m/s, metres per second; NSAA, North Star Ambulatory Assessment; s, seconds.
Fig 4.
Percentages of patients demonstrating function (NSAA item score > 0) by age and by trajectory class for four of the NSAA items.
(A) rise from floor, (B) run, (C) jump, and (D) hop on one leg. NSAA, North Star Ambulatory Assessment.
Fig 5.
Shifts in NSAA item scores over 1 year: stratification by age.
Annualised probabilities of (A) deterioration (shift down); (B) stable function (no change); or (C) improvement (shift up) in the population with DMD stratified by age groups. DMD, Duchenne muscular dystrophy; L, left; NSAA, North Star Ambulatory Assessment; R, right.
Fig 6.
Shifts in NSAA item scores over 1 year: stratification by functional status.
Annualised probabilities of shift up in NSAA item scores when stratified by (A) 10 metre walk/run and (B) rise from supine; probability of shift down in (C) 10 metre walk/run and (D) rise from supine. 10MWR, 10 metre walk/run; s, seconds; DMD, Duchenne muscular dystrophy; L, left; NSAA, North Star Ambulatory Assessment; R, right.