Table 1.
Top 10 downregulated and up-regulated genes in PD patient brain (SN).
Table 2.
Top 10 downregulated and up-regulated genes in PD patient peripheral blood.
Fig 1.
Volcano plot of the retrieved microarray data for brain, plotting the negative log10 of the adjusted P-value against the log2 of the fold change (FC).
Fig 2.
Volcano plot of the retrieved microarray data for blood, plotting the negative log10 of the adjusted P-value against the log2 of the fold change (FC).
Fig 3.
The three organizing principles of GO are biological process, cellular component and molecular function.
The histograms represent Gene Ontology (GO) analysis of the differentially expressed (Set A) mRNAs in the brain (SN) PD patients). GO terms according to the three GO organizing principles are represented on X axis. The Y-axis shows number of genes associated with GO term (P < 0.05).
Fig 4.
The three organizing principles of GO are biological process, cellular component and molecular function.
The histograms represent Gene Ontology (GO) analysis of the differentially expressed (Set A) mRNAs in the blood of PD patients. GO terms according to the three GO organizing principles are represented on X axis. The Y-axis shows number of genes associated with GO term (P < 0.05).
Fig 5.
Super pathway analyses of the differentially expressed mRNAs in PD patients (brain).
Frequency represents number of genes in the super pathway.
Fig 6.
Super pathway analyses of the differentially expressed mRNAs in PD patients (blood).
Frequency represents number of genes in the super pathway.
Fig 7.
Protein protein interaction network for the genes that are DEG in the brain and the blood.
Table 3.
List of genes that are DEG in the brain and the blood with a FC of > = 1 and > = 0.5, respectively.
TUSC3, SNCA, SLC18A2, SCN3A, PTPRN, PBX1, ORC5, OPA1, LRRN3, CHGB, CACNB2, ADAM23 were found to be downregulated in both PD brain SN and blood. XIST, MYOT, MT1H, ACACB were found to be upregulated in PD brain SN but were found to be down regulated in the blood.
Table 4.
List of genes that are DEG in the brain and the blood and have drugs available (based on the DrugBank database).
Table 5.
List of top three interacting partners and their fold change in differential expression.