Fig 1.
Synthesis of xanthonoxypropanolamines.
1a; R = H, R1 = CH2CH2CH3 1b; R = H, R1 = CH (CH3)2 2; R = OH, R1 = CH (CH3)2.
Fig 2.
Activity profile curve (i.p. route).
Fig 3.
Activity profile curve (oral route).
Table 1.
Average effect of standard drugs and test compounds (i. p. route).
Table 2.
Average effect of standard drugs and test compounds (oral route).
Fig 4.
Graphical representation of SGOT, SGPT, ALP, Albumin, total protein (Liver function test—i.p. route).
Table 3.
Comparison of liver function: Enzyme activity, Alkaline Phosphatase and proteins level.
Table 4.
Level of different parameters in serum found at Tmax after oral administration of test compounds and standard drugs atenolol [25–29] and propranolol [30–33].
Fig 5.
The binding mode of 1b (grey) in the β1 adrenoreceptor active site.
Fig 6.
Ligplot of 1b with β1 receptor active site.
Fig 7.
Binding pattern of propranolol with β1.
Fig 8.
Comparison of 1b (green) and propranolol ligand (grey) binding mode in the β1 active site.