Fig 1.
Seeds used in seed-based correlation analyses.
The following 7 seeds were selected from the Harvard-Oxford subcortical (seeds 1–6) and cortical (seed 7) atlases: 1) Left Caudate; 2) Right Caudate; 3) Left Putamen; 4) Right Putamen; 5) Left Pallidum; 6) Right Pallidum; 7) Bilateral Middle Frontal Gyrus.
Table 1.
Demographic and exposure characteristics of the participants of the pilot resting state fMRI study described here (n = 14) and of the PHIME cohort study participants who were not included in the pilot resting state fMRI study (n = 717).
Fig 2.
Results of seed-based correlation analyses.
A) positive correlation (cluster-corrected p<0.00238) between natural log-transformed early postnatal Mn concentrations and functional connectivity between the bilateral middle frontal gyrus and the left medial prefrontal cortex; B) negative correlation (cluster-corrected p<0.00238) between natural log-transformed early postnatal Mn concentrations and functional connectivity between the right putamen and the left precentral and postcentral gyrus. Note. Mn = manganese. The Mn:Ca ratio was used to quantify concentrations to account for mineral variation between and within teeth.