Fig 1.
Schematic graphs of (A) U-shaped type, (B) linear type, and (C) inverted U-shaped type.
Table 1.
Basic characteristics and cognitive measures of NC, MCI, and AD groups.
Fig 2.
Comparison of descending graph types between cortical volume, thickness, surface area, and LGI in CERAD total score.
The first and second rows show the left hemisphere from a lateral and medial view, respectively. Similarly, the third and fourth rows represent the right hemisphere from a lateral and medial view. The blue regions represent the U-shaped type and indicate sensitivity to cognitive impairment in the early stages of the Alzheimer disease. The red regions represent the linear type, showing that the ROI may be continuously damaged as the disease progresses. The yellow regions represent the inverted U-shaped type, meaning that cognitive decline is especially sensitive at the last stages. LGI local gyrification index.
Table 2.
Types of descending graph analyzed using four structural brain MRI analyses metrics using CERAD total scores in 68 ROIs.
Fig 3.
Comparison of descending graph types between cortical volume, thickness, surface area, and LGI in MMSE score.
The first and second rows show the left hemisphere from a lateral and medial view, respectively. Similarly, the third and fourth rows represent the right hemisphere from a lateral and medial view. The blue regions represent the U-shaped type and indicates sensitivity to cognitive impairment in the early stages of Alzheimer disease. The red regions represent the linear type, showing that the ROI may be continuously damaged as the disease progresses. The yellow regions represent the inverted U-shaped type, meaning that cognitive decline is most sensitive at the last stages. LGI local gyrification index.
Table 3.
Types of descending graph analyzed using four structural brain MRI analyses metrics using MMSE scores in 68 ROIs.