Fig 1.
Distribution of SNPs in different functional classes of CHK2 gene according to the dbSNP database.
Table 1.
Prediction of functional consequences of nsSNP in human CHK2.
Table 2.
ConSurf predictions of most deleterious nsSNP showing conservation profile and their post translation sites prediction by ModPred and their clinical significance in clinvar with their minor allelic frequency (MAF).
Fig 2.
Graphical representation of the position of nsSNP in CHK2 gene and protein.
Table 3.
Validation of protein structure.
Fig 3.
Ft site prediction showing Ser at 415 and Pro at 225 positions in 1st and 2nd ligand binding site respectively.
A) Pink, green and purple coloured mesh are 1st, 2nd and 3rd ligand binding site respectively of human CHK2 protein predicted using FT site server B) Zoom in on interaction at Pro 225 C) Zoom in on at Ser 415.
Table 4.
Prediction of ligand binding sites within CHK2 protein using COACH.