Fig 1.
Lesion segmentation and tumor tracking by semi-automated 3D CT volumetry of multiple pulmonary metastatic nodules.
(a) Metastatic pulmonary nodules are automatically segmented and manually edited on axial CT images of two time points using 3D visualization software. After segmentation, the 3D maximum diameter and volume of each nodule are automatically calculated. (b, c) Segmented pulmonary metastatic nodules are seen in 3D reconstructed images of baseline (b) and follow-up (c) chest CT scans.
Table 1.
The clinical features and tumor response assessment by manual CT measurement in 10 patients with multiple pulmonary metastases.
Fig 2.
Change rates in 3D maximum diameter and volume of each nodule of 10 patients.
Bar graphs show the change rates of each nodule in each patient regarding 3D maximum diameter (a) and volume (b). The x-axis of each patient’s graph means the number of nodules and the y-axis of each patient’s graph means the change rate (%) of each nodule.
Table 2.
Tumor response assessment based on the number of metastatic nodules measured by semi-automated 3D CT volumetry.
Fig 3.
Bland-Altman plots of change rates between two time points according to the number of selected nodules and the measurement method.
Plots show differences of change rates between two and total nodules estimated by 3D maximum diameter (a) and volume (b) measurements. Plots show differences of change rates between 3D maximum diameter and volume measurements in the selection of two (c) and total (d) nodules.
Fig 4.
Change ratios between two time points estimated by linear and volumetric measurements.
Scatter plots show change ratios of the 3D maximum diameter (a) and volume (b) of each nodule between two serial CT examinations. Dotted lines represent the change ratio criteria defined as 0.5 for 3D maximum diameter and 2.375 for volume in order to determine outlier nodules. Numbers above the dots are the nodule number given when performed segmentation.
Table 3.
CT spatial tumor heterogeneity of each patent’s all metastatic nodules in 10 patients.