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Fig 1.

Study flow chart.

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Fig 2.

Flow chart for patients with Aortic stenosis according to flow-gradient patterns.

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Table 1.

Baseline characteristics for non-PAD and PAD patients.

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Fig 3.

Resting Flow (RF), Peak Flow (PF), and Time-to-peak flow (tPF) in non-PAD and PAD patients.

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Table 2.

Resting flow and reactive hyperaemia values (PF and tPF) in non-PAD and PAD patients.

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Table 2 Expand

Fig 4.

ROC curves for Peak Flow at 5 seconds and Time-to-peak flow in patients without severe aortic stenosis (AS).

The curves show the predictive potential of PF at 5 seconds (solid line) and tPF (dashed line) variables with respect to PAD in patients without AS. PF at 5 seconds and tPF correlated better with ABPI in patients without AS.

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Fig 5.

ROC curves for Peak Flow at 5 seconds and Time-to-peak flow in patients with severe aortic stenosis (AS).

The curves show the predictive potential of PF at 5 seconds (solid line) and tPF (dashed line) variables with respect to PAD in patients with AS. PF at 5 seconds correlated well with ABPI; the tPF correlate less with ABPI in this group.

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Fig 6.

Scatter plot for the correlation between tPF (vertical axis) and ABPI (horizontal axis).

There is a significant correlation between tPF in PAD patients with ABPI values less than 0.7 (dash-lined box in the plot).

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Table 3.

Sensitivity, specificity, positiv predictive and negative predictive values of SGP-RH parameters (RF, PF at 5sec and tPF) in PAD patients.

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Table 3 Expand

Fig 7.

Correlation between AVA and tPF in patients with AS.

The scatter plot shows a positive trend between AVA reduction and prolonged tPF in patients with AS.

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