Table 1.
Hypothetical epidemiological scenarios for evaluating RITA performance in HIV incidence surveillance.
Table 2.
Calibrator reactivity and reproducibility of results assessed by repeat testing.
Fig 1.
Maxim vs. Sedia OD and ODn measurements.
A: Maxim vs. Sedia Optical Density (OD); B: Maxim vs. Sedia normalized Optical Density (ODn). The blue lines are linear regression fits and the red dashed lines show the diagonal (slope if the two assays produced equivalent results). C: Bland-Altman plot for Optical Density (OD); D: Bland-Altman plot for normalized Optical Density (ODn). The red lines represent zero bias, the blue solid lines the mean differences and the blue dashed lines the 95% lower and upper limits.
Table 3.
MDRI estimates for Maxim and Sedia LAg assays by HIV-1 subtype and ODn threshold, using supplemental viral load threshold of >1,000c/mL.
Fig 2.
Context-specific false-recent rate (FRR) against MDRI in three demonstrative surveillance scenarios.
A: Scenario similar to South African epidemic. B: Scenario similar to Kenyan epidemic. C: Concentrated epidemic scenario. A supplementary viral load threshold of >1,000c/mL is used throughout. We assume ARV exposure testing classifies all treated individuals as long-term. This assumption is relaxed in S4 Fig.
Fig 3.
Relative standard error (RSE) of incidence estimate against ODn threshold in three demonstrative surveillance scenarios.
A: Scenario similar to South African epidemic. B: Scenario similar to Kenyan epidemic. C. Concentrated epidemic scenario. A supplementary viral load threshold of >1,000c/mL is used throughout. We assume ARV exposure testing classifies all treated individuals as long-term. This assumption is relaxed in S5 Fig.
Table 4.
Summary recommendations for use of the Maxim and Sedia LAg assays.