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Fig 1.

Disutility typologies.

Notes: HPV = Human papillomavirus; PSA = prostate specific antigen; MRI = Magnetic resonance imaging; DRE = digital rectal examination; TRUS = trans-rectal ultrasound; LDCT = Low dose Computed Tomography; FNA = Fine needle aspiration; FOBT = fecal occult blood testing; FIT = fecal immunofluorenscence testing.

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Table 1.

Checklist for quality appraisal.

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Fig 2.

PRISMA flow chart of study selection process.

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Table 2.

Overview of the included studies (n = 38).

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Fig 3.

Overview of quality appraisal result per individual criteria.

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Fig 4.

Disutility values in screening phase.

Notes:1) Green color = high quality; Yellow color = medium quality; Grey color = low quality 2) with * values from experts; without * form general population.

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Fig 5.

Disutility values for false positive in diagnostic work up phase.

Notes: 1) Green color = high quality; Yellow color = medium quality; Grey color = low quality 2) with * values from experts; without * form general population.

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Fig 6.

Procedure-wise disutility values in diagnostic work up phase.

Notes: 1) Green color = high quality; Yellow color = medium quality; Grey color = low quality 2) with * values from experts; without * form general population 3) Different protocol: Conservative process includes observation, surveillance, follow-up with pap smear tests, aggressive process includes early colposcopy, immediate HPV tests.

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Fig 7.

Abnormal result related disutility values in diagnostic work up phase.

Notes: 1) abnormal result includes borderline or mildly dyskaryotic (BMD), cervical dysplasia, atypical squamous cells of undetermined significance (ASCUS), low-graded squamous intraepithelial lesion (LSIL), high—graded squamous intraepithelial lesion (HSIL), cervical intraepithelial neoplasia (CIN), Human papillomavirus positive 2) Green color = high quality; Yellow color = medium quality; Grey color = low quality; Dark color = very low quality 3) with * values from experts; without * form general population.

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Table 3.

Summary on measured disutility studies by typology and cancer types.

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Table 4.

Overview of the estimated disutility values.

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