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Fig 1.

Flowchart of the selection process for studies.

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Table 1.

Characteristics of included studies.

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Table 1 Expand

Fig 2.

Forest plot of the association of PPIs and risk of dementia and AD.

(A) dementia; (B) AD.

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Fig 2 Expand

Table 2.

Metaregression analysis of potential sources of heterogeneity.

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Table 2 Expand

Table 3.

Subgroup analysis.

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Table 3 Expand

Fig 3.

Funnel plot of sensitivity analysis.

(A) dementia; (B) AD.

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Fig 3 Expand

Fig 4.

Funnel plot of publication bias.

(4A) Begg’s test for all-cause dementia; (4B) Egger’s test for all-cause dementia, (4C) Begg’s test for AD; (4D) Egger’s test for AD.

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Fig 4 Expand