Table 1.
Pharmacokinetic parameters for danofloxacin in 3-week old vs. 6-month old calves with respiratory disease.
Table 2.
Population pharmacokinetic parameters for danofloxacin in 3-week old vs. 6-month old calves with respiratory disease.
Fig 1.
Mean (±SD) plasma concentrations of danofloxacin.
Danofloxacin was administered by subcutaneous route at doses of 8 mg/kg in 3-week and 6-month old calves with induced respiratory disease from P. Multocida.
Fig 2.
ISF:PlasmaTotal ratios for danofloxacin.
Ratios comparing unbound drug in ISF to total drug (bound and unbound) in plasma.
Fig 3.
Mean interstitial fluid ± SD concentrations of danofloxacin.
Danofloxacin was administered via single S.C. injection of 8 mg/kg danofloxacin in 3-week old (solid circles) and 6-month old calves (open circles).
Fig 4.
Individual PELF concentrations of danofloxacin.
Lines represent average concentration over time for 3-week old calves (solid line) and 6-month old calves (dashed line).
Table 3.
Pharmacokinetic parameters for tulathromycin in 3-week old vs. 6-month old calves with respiratory disease.
Table 4.
Population pharmacokinetic parameters for tulathromycin in 3-week old vs. 6-month old calves with respiratory disease.
Fig 5.
Mean (±SD) plasma concentrations of tulathromycin.
Tulathromycin was administered by subcutaneous route at a dose of 2.5 mg/kg in 3-week and 6-month old calves with induced respiratory disease from P. Multocida.
Fig 6.
ISF:PlasmaTotal ratios for tulathromycin.
Ratios comparing unbound drug in ISF to total drug (bound and unbound) in plasma.
Fig 7.
Mean interstitial fluid ± SD concentrations of tulathromycin.
Tulathromycin was a after single S.C. injection of 2.5 mg/kg tulathromycin in 3-week old (solid circles) and 6-month old calves (open circles).
Fig 8.
Individual PELF concentrations of tulathromycin.
Lines represent average concentration over time for 3-week old calves (solid line) and 6-month old calves (dashed line).