Fig 1.
The outline of the selection and randomization flow of patients in the study. Intent to treat (ITT), Per protocol (PP).
Fig 2.
Patients on Rebif using Rebismart were randomized to the two treatment arms at the Baseline visit. The study contained two additional assessment timepoints, at 6 and 12 months post baseline, where patients were assessed in accordance with the protocol (S1 File).
Table 1.
Baseline demographic characteristics.
Table 2.
Change from baseline to 12 months in the MSIS-29 psychological scale, 9 questions (ITT population).
Table 3.
Change from baseline to 12 months in secondary variables (ITT population).
Table 4.
Adherence (ITT population; subgroup of patients with full intervention, post-hoc analysis).