Fig 1.
No differences in family, genus or species biodiversity measures in early stage PD.
Whisker box plots indicate mean and range of Shannon alpha diversity (upper) and Bray-Curtis dissimilarity measures (lower) for the family, genus, and species levels of classification.
Fig 2.
ROC curve performance using the oral microbiome.
Empirical ROC performance during cross-validation and its 95th percentile confidence interval are shown. Overall accuracy was 84.5%.
Fig 3.
Metabolic pathway changes in oral microbiome of early stage PD.
Only 6 of the 167 KEGG pathways were changed when examining transcripts from the oral microbiome in PD subjects compared with controls.
Table 1.
Subject demographic and clinical measures.
Table 2.
PD subject characteristics.
Table 3.
Motor, cognitive, and sensory outcome measures.
Table 4.
Significantly changed microbiota in early stage PD.
Table 5.
Changes in functionally-defined metabolic pathways in early stage PD.
Table 6.
Top microbial correlations with medical/demographic/functional measures.
Table 7.
Microbiota families altered in early stage PD in the present study and prior studies.