Fig 1.
Patient selection criteria.
Table 1.
Summary of clinical characteristics.
Table 2.
Association between clinical and histological features a.
Fig 2.
Representative images of skin lesions with various clinical and histological features.
(A): Clinical image of an ulcer with black eschar and irregular violaceous border and surrounding erythema. (B): Non-ulcerated calciphylaxis lesions with plaque morphology and surrounding retiform purpura. (C): Erythematous lesions of calciphylaxis. (D): Histopathology of cutaneous calciphylaxis demonstrating ulceration, marked dermal necrosis, fibrointimal hyperplasia of a calcified medium sized vessel and subcutaneous fat necrosis with foci of acute inflammation (hematoxylin & eosin, 40x original magnification). (E): A von Kossa stain reveals presence of stippled peri-eccrine calcification (von Kossa stain, 600x original magnification). Panel F: Intravascular thrombosis in the deep dermis (hematoxylin & eosin stain, 200x original magnification).
Fig 3.
Distribution of study cohort according to the Mayo Clinic criteria [4], for likelihood of calciphylaxis diagnosis.