Fig 1.
Cluster miRNAS: Dendrogram of results of cluster analysis of miRNAs related to SLE patients.
This is the result from the interrogation of different databases in which the disease was associated with the regulation of these miRNAS, directly created from DIANA-miRPath v3.0 interface (http://www.microrna.gr/miRPathv3).
Fig 2.
Heatmap of SLE: A miRNA versus GO Slim category heatmap directly created from DIANA-miRPath v3.0 interface.
The heatmap depicts the level of enrichment of GO categories of several miRNAs in SLE patients, and enables the identification of miRNA subclasses or GO terms that characterize similar miRNAs because they are clustered together (http://www.microrna.gr/miRPathv3).
Fig 3.
Networks of miRNAS with regular expression in patients with SLE and the associated proteins post-translational modifications (PTMs) coding genes.
Green sphere corresponds to the name of the associated proteins post-translational modifications (PTMs) and gray spheres are miRNAS. On the other hand, arrows show regulation by miRNAS to the mRNA of associated proteins post-translational modifications (PTMs) coding genes.
Fig 4.
Regulatory network in miRNAs of patients with SLE (Blue rectangles), associated SLE genes, and genes associated with post-translational modifications (Pink rectangles). Black lines represent protein–miRNA interactions and red lines represent protein-protein interactions.