Fig 1.
CONSORT flowchart.
Fig 2.
A) Timeline of testing before, during and after the three-week altitude training camp (2320m), and B) the setup for the pre-and post-altitude stress-tests (VO2max ramp test or 100 m swimming).
Table 1.
Baseline characteristics.
Fig 3.
Relative change for FRAP (ferric reducing ability of plasma) and 8-epi-PGF2α in antioxidant and control groups from baseline to day 5 and 18 at altitude, and day 7 post-altitude.
Nominal p-value of < 0.05 for the group × timepoint interaction from linear mixed model regression was considered significant. The statistical analyses were carried out using R v.3.0.2 (R for statistical computing, Vienna, Austria), with packages “lme4”, “lmertest” and “emmeans”. Plots were made using the “ggplot2” package.
Fig 4.
Relative change for IL13 and IL6 in antioxidant and control group during 3-week altitude training camp (2320m).
Nominal p-values of < 0.05 for the group × timepoint interaction from linear mixed model regression were considered significant. The statistical analyses were carried out using R v.3.0.2 (R for statistical computing, Vienna, Austria), with packages “lme4”, “lmertest” and “emmeans”. Plots were made using the “ggplot2” package.
Fig 5.
The change in log-transformed plasma cytokine concentrations in response to exercise stress-test (VO2max ramp test/100 m swimming) pre- and post-altitude presented as delta (Δ) (post-test concentration − Pre-test concentration).
P-values were calculated using ordinary least squares regression with Δ as the outcome variable and time (post-altitude vs. pre-altitude) as the predictor.