Fig 1.
CNV calling was conducted using variants detected by two or three calling algorithms, which were of sizes greater than 5 kb and spanned at least five array probes. SD: Standard deviation; LRR: Log R ratio; BAF: B allele frequency.
Fig 2.
Chromosome view of detected CNVs.
The CNVs are presented as tiles on the corresponding genomic positions. The colour of the tile indicates the CNV type: deletions are red, duplications are blue. The height of tile stack in each genomic region corresponds to the number of CNVs; if genomic region contains more than 25 CNVs, only 25 tiles are presented. The genes intersected by rare CNVs and significantly (Padj<0.01) associated with IBD are marked by red (for deleted genes) or blue (for duplicated genes) labels; the colocated genes overlapped by the same CNVs with no significant IBD association are not presented. The regions contained the genes intersected by rare CNVs significantly associated with IBD are zoomed in 1000 times and highlighted (red and blue highlights for the associated deletions and duplications, correspondingly). The figure was built using the Circos[35] tool.
Table 1.
All CNVs, genic CNVs and no genic CNVs of different lengths observed in the samples from CD and UC populations.
Summary data for all CNV types and separated data for deletions and duplications are provided.
Table 2.
The genes affected by rare CNVs overrepresented in IBD population.