Fig 1.
Manhattan plot of SNP-QRS associations.
Manhattan plot showing the association of SNPs with QRS duration in the GWAS meta-analysis containing 15,124 individuals of Hispanic/Latino ethnicity. The horizontal line represents the genome-wide significance threshold of (P = 5E-08). SNPs mapping to 6 loci exceeded the GWAS threshold for significance.
Table 1.
Genome-wide significant SNPs identified in a GWAS meta-analysis of n = 15,124 participants of Hispanic/Latino ancestry from four studies.
Fig 2.
Transethnic comparison of QRS effect sizes for Hispanic/Latino SNPs.
Comparison of effect sizes and 95% confidence intervals for the 9 index SNPs that were genome-wide significant in the Hispanic/Latino QRS duration GWAS, and the effect sizes for corresponding SNPs in the European and African American GWAS. SNP rs10428132 was not directly measured in the European or African American studies, but instead a SNP in perfect LD (r2 = 1) was used (rs6800541). Other SNPs that were not directly measured in Europeans or African Americans are not presented (rs62241190, rs9856387, rs3176326, and rs16946539). * Refers to SNPs where the difference in effect size between two ethnic groups was significant at the Bonferroni corrected P-value. Two SNPs showed larger effects in Hispanics/Latinos than in European-descent individuals: rs3922844 in SCN5A and rs4842438 in SYT1. See S7 Table for additional details.
Fig 3.
Regional association plots of SCN5A-SCN10A.
A (top-left)–Hispanic/Latino GWAS. B (top right)–European GWAS. C (bottom left)–African American GWAS. Plots created with LocusZoom software.[20] The most significant SNP identified in the Hispanic Latino and African American GWAS was rs3922844 in SCN5A. The most significant SNP in the European GWAS was rs6801957 in SCN10A.
Fig 4.
Transethnic comparison of QRS effect sizes for previously known SNPs.
Comparison of effect sizes and 95% confidence intervals for 28 previously discovered SNPs for QRS duration across European, Hispanic/Latino, and African American GWAS results. Findings are largely similar across ethnic groups. * Refers to SNPs where the difference in effect size between two ethnic groups was significant at the Bonferroni corrected P-value. See S7 Table for additional details.
Table 2.
Comparison of the effect size and significance level of QRS prolonging index SNPs with QT and PR duration in Hispanics/Latinos. There was no association of QRS SNPs with heart rate or heart rate variability (SDNN). Only significant results (P<0.05) are shown.