Fig 1.
Decision tree with base case input values.
The decision tree is a graphical display of a logical sequence of events in the two study arms. The square represents the decision node from which the two competing strategies (molecular method plus blood cultures vs. blood cultures alone) originate. The circles are chance nodes that lead to a particular outcome (e.g. survival or death) beyond the control of our decision. The probabilities assigned to the decision tree are for baseline analysis and are listed in Table 1.
Table 1.
Model inputs and baseline estimates.
Fig 2.
One-way sensitivity analysis for assay cost.
One-way sensitivity analysis when assay cost ranges from $100–1,000 for all 4 base case scenarios (i.e. when the difference in hospital length of stay between patients receiving appropriate and inappropriate antimicrobial therapy is 0, 2 and 4 days).
Fig 3.
One-way sensitivity analysis for assay sensitivity.
One-way sensitivity analysis when the sensitivity of the assay ranges from 50%-95% for all 4 base case scenarios (i.e. when the difference in hospital length of stay between patients receiving appropriate and inappropriate antimicrobial therapy is 0, 2 and 4 days).
Fig 4.
One-way sensitivity analysis for assay efficiency.
One-way sensitivity analysis when the efficiency of the assay ranges from 30%-95% for all 4 base case scenarios (i.e. when the difference in hospital length of stay between patients receiving appropriate and inappropriate antimicrobial therapy is 0, 2 and 4 days.