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Fig 1.

Annual incidence and number of probable cases of HFMD in Neijiang, China, 2010–2017.

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Fig 2.

Monthly distribution of the probable HFMD cases in Neijiang, Sichuan, China, 2010–2017.

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Table 1.

The demographic characteristics of probable hand, foot and mouth disease cases in Neijiang, Sichuan, China between 2010 and 2017 (N, %) a.

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Fig 3.

Flow diagram of the epidemiology and genotype investigation of HFMD patients.

EV-A71 = enterovirus A71. CV-A16 = coxsackievirus A16. *Classification according to the criteria issued by National Health and Family Planning Commission of the People’s Republic of China.

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Fig 3 Expand

Fig 4.

The yearly and monthly distribution and constituent ratio of the enterovirus serotype associated with confirmed HFMD cases in Neijiang, Sichuan, China, 2012–2017.

A) Yearly distribution; B) Monthly distribution.

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Fig 5.

Enterovirus serotype distribution by age group in confirmed HFMD cases in Neijiang, Sichuan, China, 2012–2017.

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Fig 6.

Phylogenic tree of EV71 (n = 23) and CV-A16 (n = 24) from Neijiang city.

A) EV71; B) CV-A16; Red triangle, sequences from Neijiang city; Black sphere, reference sequences.

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Fig 6 Expand