Fig 1.
Typical 1H NMR spectrum of serum (400 MHz, D2O, Presat-CPMG pulse sequence) used in the study.
Table 1.
Clinical data of studied volunteers.
Fig 2.
PCA results using all dataset.
On the left, score plot (PC1xPC2, 71% of variance)—control (red circles), osteoporosis (green squares) and osteopenia (blue triangles); The right, loading plot indicates the most important variables for discrimination.
Table 2.
Samples classification based on scores obtained from LDA Model using fifty 1H NMR spectra– 26 osteopenia and 24 osteoporosis.
Fig 3.
OPLS-DA results using only osteoporosis (green squares) and osteopenia (blue triangles) samples from postmenopausal women.
Score plot (at left) and VIP score plot (at right).
Table 3.
Identification of metabolites in the metabonomics model responsible for discrimination among groups.