Fig 1.
Study protocol overview.
Fig 2.
Example of SUIT high resolution respirometry protocol.
The two measurements performed in the presence of propofol (μg/ml) or vehicle (ethanol) as control.
Fig 3.
Prediction of difference of respiratory parameters against control at different concentration of propofol.
Graph A–respiration chain capacity, graph B–complex I, graph C–LEAK, graph D—complex II, graph E–FAO, graph F–complex IV.
Fig 4.
Kinetics of inhibition by 2.5 μg/ml and 10 μg/ml of propofol in human muscle homogenates (left and middle figures), and by 10 μg/ml in rat muscle homogenates (right figure).
A = Complex I in heart tissue. B = Complex I in skeletal muscle. C = FAO in heart tissue. D = FAO in skeletal muscle. Based on multi-level linear regression model of independent measurements in all subjects. Note: FAO = fatty acid oxidation, OCR = oxygen consumption rate.