Fig 1.
Quantitative analyses of choroidal neovascularization.
(a) The CNV-containing slab was generated with the segmentation from the lower edge of the outer nuclear layer to either the retinal pigment epithelium or the line of Bruch’s membrane. (b) The CNV image free of projection artifacts was generated by subtraction of the retinal vessel image. (c) An open-source software (AngioTool) measured the vessel area surrounded by green lines, the vessel length indicated by red lines, and junction number with blue points.
Table 1.
Patients’ demographics and characteristics.
Fig 2.
A case of Type 1 choroidal neovascularization.
Left eye images of a 74-year-old woman with a visual acuity of 20/32. (a) Mid-phase fluorescein angiography showing leakage from an undetermined source. (b) Indocyanine green angiography showing a neovascular membrane. (c) 3 × 3-mm en face optical coherence tomography angiography (OCTA) images after removal of projection artifacts. The vessel branches radiate in all directions from the center of the lesion (medusa pattern). Note that the central vessels show trunk-like vessels. (d and e) Corresponding B-scan images showing segmentation lines (d) and flow signals overlaid on the B-scan image (e).
Fig 3.
A case of Type 2 choroidal neovascularization (CNV).
Right eye images of a 66-year-old woman with a visual acuity of 20/32. (a) Early-phase fluorescein angiography showing neovascular vessels that indicates a predominantly classic CNV. (b) Indocyanine green angiography showing the entire CNV. (c) 3 × 3-mm en face optical coherence tomography angiography (OCTA) images after removal of projection artifacts showing the dense small vessels. Note that the area corresponding with type 2 CNV (arrows) seems more vessel-dense compared to the area corresponding with type 1 CNV (arrow heads). (d) Corresponding B-scan images showing the segmentation lines. (e) Corresponding B-scan images with flow signals. Note the abnormal signals above and beneath the RPE, indicating that the lesion contains both type 1 and type 2 CNVs.
Fig 4.
A case of Type 2 choroidal neovascularization (CNV).
Left eye images of a 70-year-old female patient with a visual acuity of 20/25. (a) Mid-phase fluorescein angiography showing intense leakage and indicating a classic CNV type. (b) Indocyanine green angiography showing the neovascular vessels. (c) 3 × 3-mm en face optical coherence tomography angiography (OCTA) images after removal of projection artifacts showing the dense small vessels. (d and e) Corresponding B-scan images showing the segmentation lines (d) and flow signals overlaid on the B-scan image (e).
Fig 5.
Quantitative and qualitative choroidal neovascularization (CNV) analyses.
Vessel area (a), vessel length (b), and vessel junction density per length (c) of type 1 and type 2 CNVs. *Statistically significant difference (P < 0.05). N.S., not significant.
Table 2.
Vessel area, vessel length, and vessel junction density on optical coherence tomography angiography in eyes with Type 1 and Type 2 choroidal neovascularization.