Fig 1.
Chemical structures of HEMA and crosslinkers EGDMA, VM, AM, and AHPM.
Table 1.
All hydrogels were synthesized with a 12.5/4.2/26.3 molar ratio of HEMA/crosslinker/UPW, while the chemical crosslinker or ratio of crosslinkers was varied.
Fig 2.
Young’s modulus vs. toughness under physiological conditions for HEMA-based hydrogels photocrosslinked at multiple time points.
Chemical formulations are outlined in Table 1. UV exposure times varied across different formulations to achieve the widest possible range in modulus; exposure times for each data point are presented in S1 Fig.
Fig 3.
Toughness as a function of equilibrium water content for the hydrogels with formulations described in Table 1.
Fig 4.
Human dermal fibroblast viability after 72 hours of co-culture with VM crosslinked and EGDMA/VM co-crosslinked HEMA hydrogels at low and high crosslinking densities.