Fig 1.
The volume of water intake and the urine volume.
(A) The volume of water intake (ml). Significant differences (P<0.05) were observed between C and WH (p<0.0147), and H and WH (p = 0.0149). (B) The urine volume at 15 weeks (ml). Significant differences (P<0.05) were observed between C and W (p = 0.0445), C and WH (p = 0.0150), and W and H (p = 0.0011).
Fig 2.
The BUN concentrations and the serum concentrations.
(A) The BUN concentrations at 15 weeks (mg/dl). Significant differences (P<0.05) were observed between C and W (p = 0.0010), C and WH (p = 0.0010), W and H (p = 0.0168), and H and WH (p = 0.0365). (B) The serum Cr concentrations at 15 weeks (mg/dl). No significant differences (p<0.05) were observed between any of the groups.
Fig 3.
The ratio of kidney weight to body weight.
The ratio of kidney weight to body weight at 15 weeks (%). Significant differences (P<0.05) were observed between C and W (p = 0.0010), W and H (p = 0.0019), W and WH (p = 0.0029), and H and WH (p = 0.0317).
Fig 4.
The cross-section of the right kidney.
(A) The ratio of the area of cysts in the cross-section of the right kidney at 15 weeks (%). No significant differences (p<0.05) were observed between any of the groups. (B) A typical cross-section of right kidney in each group.