Fig 1.
BCT, barbiturate coma therapy.
Table 1.
Baseline characteristics of barbiturate coma therapy.
Table 2.
Clinical characteristics and outcomes.
Table 3.
Factors associated with barbiturate coma therapy during tumor surgery.
Fig 2.
ICP patterns in 20 patients with established RICH before BCT, and monitored from 6 h before BCT.
Four patients had favorable neurological outcome while 16 patients had poor neurological outcome. The ICP curves show the means ± standard deviation at each monitoring time. ICP, intracranial pressure; RICH, refractory intracranial hypertension; BCT, barbiturate coma therapy.
Fig 3.
Receiver operating characteristic (ROC) curves for the prediction of clinical outcomes.
ROC curves for the prediction of (A) poor neurological outcome and (B) hospital mortality associated with maximal intracranial pressure within 6 h after barbiturate coma therapy (n = 60).
Fig 4.
Kaplan-Meier three-month survival curves according to maximal intracranial pressure within 6 h after barbiturate coma therapy.
Blue solid line, under 22 mm Hg; red solid line, over 22 mm Hg; adjusted hazard ratio 8.16, 95% CI, 2.373–28.056, p < 0.001, based on log-rank tests (n = 60).
Table 4.
Univariable and multivariable analyses of factors associated with clinical outcomes.