Table 1.
Demographics information.
Fig 1.
Optical coherence tomography angiography (OCTA) segmentation of the disc and macula.
(A) shows a 4.5 x 4.5mm2 en face OCTA image of the radial peripapillary capillary (RPC) centered on the optic disc of a healthy control, and (D) shows the cross-section segmentation of the RPC. (B) shows the en face image of the superficial vascular complex (SVC) segmentation obtained from the same individual with (E) showing the cross-section of SVC. (C) shows 3.0 x 3.0mm2 en face scan of the superficial capillary plexus (SCP) centered on the of the fovea of the same individual with (F) showing the cross-section segmentation of the SCP.
Fig 2.
Parafoveal and peripapillary image analysis.
A healthy control’s angiograms show the superficial capillary plexus (SCP) of the macula with delineation of the parafovea between rings of 1.0mm and 3.0mm (A), after binarization of parafoveal vessels based on a background defined by the foveal avascular zone (B), and after skeletonizing all vessels to be one pixel wide (C). Bottom row shows the radial papillary capillary (RPC) layer of the same individual with the peripapillary area between rings of 2.0mm and 4.0mm centered on the optic disc and the superior quadrant of the peripapillary delineated in orange (D). Thresholding and binarization with the Phansalkar method in the peripapillary are shown (E). The large vessel masks in RPC (F) was removed from RPC images to obtain the microcapillary vessel density.
Table 2.
Comparison of macular and disc optical coherence tomography angiography parameter means between participants with cognitive impairment and cognitively normal controls.
Table 3.
Pearson and Spearman correlation between Montreal Cognitive Assessment scores and optical coherence tomography angiography parameters.