Fig 1.
Schematic drawing of airway parameters.
WA, wall area; LA, lumen area; AA, airway area; LAD, lumen average diameter; AAD, airway average diameter; WT, wall thickness.
Table 1.
Patients’ demographics.
Fig 2.
A representative case of successful quantitative analysis of a four-year-old girl with post-infectious bronchiolitis obliterans.
(A) The coronal reconstructed CT image demonstrates bronchial wall thickening with mosaic attenuation in bilateral lungs. (B and C) Automatic airway segmentation (B) and subsequent manual editing (C) reveal all segmental bronchi in bilateral lungs. (D) Each segment is labeled. (E) Small regions of interest are drawn at normal and obviously air-trapping lung parenchyma to calculate the individualized threshold value of air-trapping. (F) Lung parenchyma area with CT attenuation value lower than the calculated threshold is marked with orange.
Fig 3.
A representative case showing failure of an attempted quantitative airway analysis of a four-year-old boy with post-infectious bronchiolitis obliterans.
(A) An axial CT image shows atelectasis of right middle lobe and left lower lobe. Airways are not delineable in the affected areas. (B) Airway segmentation failed in the corresponding and distal regions.
Table 2.
Quantitative CT airway and air-trapping parameters measured in 23 post-infectious bronchiolitis obliterans patients.
Fig 4.
Scatter plots for each lobe of both lungs.
Scatter plots demonstrating the correlation of wall area (WA) or air-trapping volume (ATV) with pre-bronchodilator forced expiration volume in one second (FEV1) in each pulmonary lobe of both lungs.
Table 3.
Correlations between airway parameters and pre-bronchodilator FEV1.
Table 4.
Correlations between air-trapping parameters and pre-bronchodilator FEV1.