Table 1.
Titers of HSV-specific neutralizing antibody in positive control serum measured by ELVIS and traditional PRNT assays.
Fig 1.
Correlation between anti-HSV titers of sera from women vaccinated with HSV-gD2 vaccine in ELVIS and traditional PRNT assays.
Month 7 sera were diluted and tested simultaneously in ELVIS and traditional PRNT assays. Dots represent individual serum samples, with marker shapes indicating previously reported ELISA titer level [9]. Solid lines indicate predicted values from linear regression analysis with the shaded band showing the 95% confidence interval and the dashed lines showing the 95% prediction interval A) HSV-1 (R2 = 0.87); B) HSV-2 (R2 = 0.78).
Table 2.
Geometric mean titers (95% confidence interval) of ELVIS and traditional PRNT and ELISA assays on Herpevac Trial sera in the presence of complement.
Fig 2.
Correlation between anti-HSV titers of sera in ELVIS and traditional PRNT assays in the presence and absence of added complement.
Nine month 7 sera were diluted and tested simultaneously in ELVIS and traditional PRNT assays. Dots represent individual serum samples, with marker shapes indicating previously reported ELISA titer level [9]. Solid lines indicate predicted values from linear regression analysis with the shaded band showing the 95% confidence interval and the dashed lines showing the 95% prediction interval. A) Anti-HSV-1 or B) anti-HSV-2 with complement; C) anti-HSV-1 or D) and-HSV-2 without added complement.