Fig 1.
Chemical structure of (a) ALP (b) OXP (c) LES and (d) IS.
Fig 2.
Fragment ions spectra of (a) ALP (b) OXP (c) LES and (d) IS.
Table 1.
Optimized compound specific parameters for ALP, OXP, LES and IS.
Fig 3.
The representative MRM chromatograms of ALP, OXP, LES and IS in (a) blank rat plasma and (b) plasma spiked at LLOQ concentrations.
Table 2.
Inter and inter-day precision and accuracy data of ALP, OXP and LES in rat plasma.
Table 3.
Extraction recovery and matrix effects data of ALP, OXP, LES and IS in rat plasma (n = 5).
Fig 4.
The representative MRM chromatograms of ALP, OXP, LES and IS at one h after oral administration of ALP (20 mg/kg) and LES (15 mg/kg).
Fig 5.
The plasma concentration-time profile of ALP, OXP, LES after oral administration of ALP (20 mg/kg) and LES (15 mg/kg).
Table 4.
The non-compartmental pharmacokinetic parameters for ALP, OXP and LES in rat plasma after oral administration of mg/kg of ALP and 15 mg/kg of LES.