Fig 1.
Correlation between telomere and G-tail length.
(A) Correlation between B-RTL and B-RGL (y = 0.67 x—0.26, r2 = 0.622, p < 0.001). (B) Correlation between L-RTL and L-RGL (y = 0.58 x + 0.21, r2 = 0.175, p = 0.002). B-RTL; relative telomere length from blood, B-RGL; relative G-tail length from blood, L-RTL; relative telomere length from liver, L-RGL; relative G-tail length from liver.
Table 1.
Clinical characteristics of patients.
Fig 2.
Correlation between telomere/G-tail length from blood and liver.
(A) Correlation between B-RTL and L-RTL (y = 0.03 x + 2.35, r2 = 0.007, p = 0.552). (B) Correlation between B-RGL and L-RGL (y = 0.05 x + 1.54, r2 = 0.006, p = 0.583). B-RTL; relative telomere length from blood, L-RTL; relative telomere length from liver, B-RGL; relative G-tail length from blood, L-RGL; relative G-tail length from liver.
Fig 3.
Correlation between telomere/G-tail length and age.
(A) Correlation between B-RTL and age (y = -0.03 x + 5.87, r2 = 0.096, p = 0.021). (B) Correlation between B-RGL and age (y = -0.01 x + 3.17, r2 = 0.011, p = 0.437). (C) Correlation between L-RTL and age (y = -0.002 x + 2.58, r2 = 0.003, p = 0.679). (D) Correlation between L-RGL and age (y = -0.006 x + 1.89, r2 = 0.010, p = 0.468). B-RTL; relative telomere length from blood, B-RGL; relative G-tail length from blood, L-RTL; relative telomere length from liver, L-RGL; relative G-tail length from liver.
Table 2.
Clinical characteristics of liver donors according to PHLF.
Fig 4.
The correlation between age and liver regeneration.
(A) Age and ERI in all donors (y = 0.342 x + 25.0, r2 = 0.025, p = 0.246). (B) Age and ERI in donors who underwent left hemihepatectomy (y = -0.091 x + 27.7, r2 = 0.006, p = 0.690). (C) Age and ERI in donors who underwent right hemihepatectomy (y = 0.853 x + 23.5, r2 = 0.159, p = 0.054). ERI; early regeneration index.
Fig 5.
Correlation between telomere/G-tail length from blood and liver regeneration.
(A) B-RTL and ERI in all donors (y = - 2.08 x + 47.6, r2 = 0.011, p = 0.440). (B) B-RGL and ERI in all donors (y = - 2.65 x + 45.6, r2 = 0.013, p = 0.403). (C) B-RTL and ERI in donors who underwent left hemihepatectomy (y = 0.71 x + 20.9, r2 = 0.005, p = 0.697). (D) B-RGL and ERI in donors who underwent left hemihepatectomy (y = - 0.15 x + 24.6, r2 < 0.001, p = 0.952). (E) B-RTL and ERI in donors who underwent right hemihepatectomy (y = - 5.98 x + 83.0, r2 = 0.064, p = 0.232). (F) B-RGL and ERI in donors who underwent right hemihepatectomy (y = - 8.50 x + 81.2, r2 = 0.138, p = 0.074). ERI; early regeneration index.
Fig 6.
Correlation between telomere/G-tail length from liver tissue and liver regeneration.
(A) L-RTL and ERI in all donors (y = - 12.0 x + 68.1, r2 = 0.052, p = 0.094). (B) L-RGL and ERI in all donors (y = - 9.34 x + 53.8, r2 = 0.062, p = 0.068). (C) L-RTL and ERI in donors who underwent left hemihepatectomy (y = - 2.66 x + 30.9, r2 = 0.012, p = 0.558). (D) L-RGL and ERI in donors who underwent left hemihepatectomy (y = - 3.94 x + 31.0, r2 = 0.022, p = 0.424). (E) L-RTL and ERI in donors who underwent right hemihepatectomy (y = - 34.9 x + 141.2, r2 = 0.183, p = 0.037). (F) L-RGL and ERI in donors who underwent right hemihepatectomy (y = - 8.82 x + 70.3, r2 = 0.076, p = 0.193). ERI; early regeneration index.
Fig 7.
Survival curves of recipients after LDLT.
(A) Comparison of the cumulative survival curves stratified with B-RTL (< 4.6 x 105 rfu, red line, and ≥ 4.6 x 105 rfu, blue line). (B) Comparison of the cumulative survival curves stratified with L-RTL (< 2.7 x 105 rfu, red line, and ≥ 2.7 x 105 rfu, blue line). (C) Comparison of the cumulative survival curves stratified with donor age (< 45 years old, red line, vs ≥ 45 years old, blue line). (D) Comparison of the cumulative survival curves stratified with MELD score (< 18, red line, and ≥ 18, blue line).
Table 3.
Prognostic factors of recipients after liver transplantation.