Table 1.
Clinical details of the patient cohort.
Fig 1.
Normal M1 activation in a glioblastoma patient (ID 5) without signs of cortical M1 reorganization; white lines indicating the slice intersections, color coding bars on right-hand side of panels B and C indicate correlation values and magnetic field strength, respectively. (A) Cranial contrast-enhanced T1w MRI in axial, coronal and sagittal orientation (left to right). (B) fMRI localization of M1 superimposed onto a native T1w MRI. (C) MEG localization of M1 superimposed onto a native T1w MRI. fMRI- and MEG-based cortical localizations show a high degree of spatial congruency.
Fig 2.
Cortical reorganization of the M1 activation.
Cortical reorganization of the M1 activation in patient with anaplastic astrocytoma (ID 4) and signs of cortical M1 reorganization. Axial, coronal and sagittal planes are ordered from left to right with white lines indicating the slice intersections; color coding bars on right-hand side of the sagittal planes in A and B/C indicate correlation values and magnetic field strength, respectively. The diagrams on right-hand side of the composite show the block paradigm with the fMRI signal intensities in the selected voxel in A and the time courses of the magnetic field strength within the MEG data in the areas with M1 activation in B/C. (A) fMRI localization of M1 superimposed onto a native T1w MRI. (B/C) MEG localization of M1 superimposed onto a native T1w MRI. The latency difference between ipsi- (B) and contralateral (C) M1 activation was 62 ms. fMRI- and MEG-based cortical localizations show a high degree of spatial congruency in the between the contralateral, normal (B) and ipsilateral, reorganized (C) M1 areas.
Table 2.
Spatial comparison of three different MEG localization methods.
Table 3.
Spatial comparison of fMRI and the three different MEG localization methods.
Table 4.
Spatial comparison of the fMRI off-border localization and the three different MEG localization methods.
Fig 3.
Distances between M1 and the tumor border.
Distances between the border of the cortical M1 activation in fMRI and tumor border on 3D T1w MRI (contrast enhanced, CE and native) for patients with and without reorganization of the M1 area.
Fig 4.
M1 time lines of cortical M1 reorganization.
M1 time lines of the magnetic field strength (calculated by MNE) in a patient with anaplastic astrocytoma (ID 4) and signs of cortical M1 reorganization. The blue and red traces depict the magnetic field strength originating from the contralateral, normal and ipsilateral, reorganized M1 areas with a delay of 62ms. The green traces depict the magnetic field strength originating from the contralateral ipsilateral PMA area.