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Table 1.

List of principal quantities.

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Table 1 Expand

Fig 1.

Computational domain decomposition.

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Fig 1 Expand

Fig 2.

Schema of contact model.

(a) The interaction force in the adhesive contact model. (b) The relationship between the contact force and the distance r0.

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Fig 2 Expand

Fig 3.

Schema of fluid–structure interaction models.

(a) The interpolation of velocity from solid to fluid. (b) The interpolation of traction from fluid to solid.

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Fig 3 Expand

Fig 4.

Geometry and size of the venous model.

(a) Vein sample (obtained from [17]). (b) 3D structure. (c) 2D model.

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Fig 4 Expand

Table 2.

Dimensional parameters of the vein model.

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Table 2 Expand

Table 3.

Material properties of the three parts of the vein model.

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Table 3 Expand

Fig 5.

Prescribed boundary conditions.

(a) Inlet pressure boundary condition, inlet velocity boundary condition, and gravity. (b) Pulsed-wave function.

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Fig 5 Expand

Table 4.

Material properties of the bileaflet valves with mechanical lesion.

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Table 4 Expand

Fig 6.

Various valve configurations and flow streamlines in a normal valve cycle.

(a) In the opening phase, 0.08 s. (b) In the equilibrium phase, 0.30 s. (c) In the closing phase, 0.51 s. (d) In the closed phase, 0.8 s. (e) In the closed phase, 1.0 s.

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Fig 6 Expand

Fig 7.

(a) Time variations of the venous behavior: A, opening phase, 0.05–0.20 s; B, equilibrium phase, 0.20–0.39 s; C, closing phase, 0.39–0.68 s; and D, closed phase, 0.68–1.05 s. Δd’wa is the displacement of the marked position on the anterior wall, Δd’wp is the displacement of the marked position on the posterior wall, and Δd’s is the displacement of the sinus. (b) Time variation of the geometric orifice area AGOA.

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Fig 7 Expand

Fig 8.

(a) Velocity distributions at the orifice. (b) Flow rate at the inlet, orifice, and outlet.

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Fig 8 Expand

Fig 9.

Contours of the pressure and the first principal strain (MPSN) at the maximum opening orifice and the closed valve configuration.

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Fig 9 Expand

Fig 10.

WSSs of blood and valve.

(a) In the maximum opening state, 0.30 s. (b) In the closed state, 1.00 s.

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Fig 10 Expand

Fig 11.

Time variation of the GOA.

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Fig 11 Expand

Fig 12.

Valve configuration and flow streamlines in the cases of (a) CAV and (b) IAV at 1.00 s.

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Fig 12 Expand

Fig 13.

Normalized maximum velocity of (a) the transvalvular flow and (b) the outflow. The maximum velocities for the normal valve are calibrated to 100%.

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Fig 13 Expand

Table 5.

Venous volume and the related time of different valves for one cycle.

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Table 5 Expand

Fig 14.

Maximum WSS of (a) the blood and (b) the leaflet for different cases.

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Fig 14 Expand

Fig 15.

Blood and leaflet WSSs (a) at 0.30s and (b) at 1.0 s for the IAV.

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Fig 15 Expand

Fig 16.

(a) Blood and leaflet WSSs in the closed phase for the CFV. (b) Mechanical cost of the valve for different cases. (c) SWSS and (d) FWSS at the leaflet backside.

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Fig 16 Expand