Table 1.
List of AAV vectors, multiplicity of infection (MOI) values and cell lines used for the transduction inhibition assay.
Fig 1.
Prevalence of pre-existing NAb against AAV serotypes in client-owned domestic cats from Switzerland depicted according to titers.
The percentage of NAb against different AAV serotypes is shown for serum dilutions of ≥1:10; ≥1:20, ≥1:40, ≥1:80 and ≥1:160. NAb against AAV7, AAV8 and AAV9 were the most prevalent; NAb against AAV1, AAV5 and AAV6 were the least prevalent.
Fig 2.
Geographic origin of cats with NAb against AAV in Switzerland.
NAb against A) AAV1, B) AAV2, C) AAV5, D) AAV6, E) AAV7, F) AAV8, and G) AAV9 are shown. Dots represent samples with positive NAb against an AAV serotype. Higher color intensity refers to higher positive NAb titers, with 1:160 being the darkest. Black dots represent geographic locations where more than one sample with a positive NAb was found. In this case, all positive samples are clustered around the black dot.
Table 2.
Linkage of seroreactivity (RAB) between AAV serotypes in client-owned cats in Switzerland (NAb titer: 1:10).
Table 3.
Overview of the prevalence (in %) of NAb to AAV in various animal species.