Fig 1.
Phantom model with inserts with different concentrations of iodine (QRM GmbH, Forchheim, Germany).
Fig 2.
Phantom sample with blood and inserts with varying iodine concentrations as indicated in the image.
(A) Conventional CT, where blood cannot be differentiated from the lower iodine concentrations. (B) Iodine map, where lower iodine concentrations are discernible from the blood sample. Visually, already the smallest measured iodine concentration of 0.5 mg/ml can be discriminated from blood.
Fig 3.
Scatter plot showing correlation between iodine concentration measured with SPCCT and true iodine concentration contained in the phantom (R2 = 0.9993, p < 0.03).
Fig 4.
Bland-Altman plot showing difference between true and measured iodine concentrations versus average of true and measured iodine concentrations.
The black line represents the bias and the dashed lines represent upper and lower limits of the mean (confidence limits ± 1.96).
Fig 5.
Tubes with blood or iodine-based contrast material positioned in bovine brain tissue (ex vivo).
In conventional CT (left) the content of the tubes cannot be differentiated due to similar HU values. In the iodine (middle) and overlay (right) image the tubes are clearly distinguishable due to the decomposition algorithm.